Research

I am moving my lab to Purdue University, Department of Biochemistry, in July of 2008. My new faculty page is here.

Selected Publications

• Schaefer, J., Jiang, H., Ransome, A. E., and Kappock, T. J. (2007) Multiple active site histidine protonation states in Acetobacter aceti N⁵-carboxyaminoimidazole ribonucleotide mutase (PurE) detected by REDOR NMR. Biochemistry 46, 9507-9512. DOI
• Hoskins, A. A., Morar, M., Kappock, T. J., Mathews, I. I., Zaugg, J. B., Barder, T. E., Peng, P., Okamoto, A., Ealick, S. E., and Stubbe, J. (2007) N⁵-CAIR mutase: Role of a CO₂ binding site and substrate movement in catalysis. Biochemistry 46, 2842-2855. DOI
• Nam, J.-W., and Kappock, T. J. (2007) Cloning and transcriptional analysis of Crepis alpina fatty acid desaturases affecting the biosynthesis of crepenynic acid. J. Exp. Bot. 58, 1421-1432. DOI
• Starks, C. M., Francois, J. A., MacArthur, K. M., Heard, B. Z., and Kappock, T. J. (2007) Atomic-resolution crystal structure of Acetobacter aceti thioredoxin, a thiol-disulfide exchange catalyst that functions at low pH. Protein Sci.16, 92-98. DOI
• Francois, J. A., and Kappock, T. J. (2007) Alanine racemase from the acidophile Acetobacter aceti. Protein Expr. Purif. 51, 39-48. DOI
• Francois, J. A., Starks, C. M., Sivanuntakorn, S., Jiang, H., Ransome, A. E., Nam, J.-W., Constantine, C. Z., and Kappock, T. J. (2006) Structure of an NADH-insensitive hexameric citrate synthase that resists acid inactivation. Biochemistry 45, 13487-13499. DOI
• Constantine, C. Z., Starks, C. M., Mill, C. P., Ransome, A. E., Karpowicz, S. J., Francois, J. A., Goodman, R. A., and Kappock, T. J. (2006) Biochemical and structural studies of N⁵-carboxyaminoimidazole ribonucleotide mutase (PurE) from the acidophilic bacterium Acetobacter aceti. Biochemistry 45, 8193-8208. DOI
• Kappock, T. J., Ealick, S. E., and Stubbe, J. (2000) Modular evolution of the purine biosynthetic pathway. Curr. Opin. Chem. Biol. 4, 567-572. DOI