John-Stephen Taylor

Titles: 
Professor, Department of Chemistry

Office Contact Information

Degrees: 
Postdoctoral Fellow, Caltech 1981-1983
Degrees: 
Ph.D. Columbia University
Degrees: 
S.B. Massachusetts Institute of Technology
Office: 
Lab Sciences 401A
Mailbox: 

Campus Box 1134

Phone: 
314-935-6721
Fax: 
314-935-4481
Email: 
taylor@wustl.edu

Research specialization

Centers
Awards & Honors: 

1975, Phi Beta Kappa, MIT
1976, Merck Index Award for Scholastic Excellence in Chemistry, MIT
1977, 1978, Teaching Award, Columbia University
1981, Pegram Award for Outstanding Graduate Work, Columbia University
1981 - 1983, Damon Runyon-Walter Winchell Cancer Fund Fellow
1988 - 1990, Alfred P. Sloan Foundation Fellow
1993 - 2001, NIH Merit Award
1993, American Chemical Society St. Louis Award
2005-2007, Special Recognition for Excellence in Mentoring, Washington University

Appointments

2001-present, Member of the Siteman Cancer Center
1997-present, Professor of Chemistry, Washington University
1990-present, Member of the Division of Biomedical Sciences, Molecular Biology
1990-1997, Associate Professor of Chemistry, Washington University
1983-1990, Assistant Professor of Chemistry, Washington University
1981-1983, Postdoctoral Associate, California Institute of Technology

Publications

Nucleic Acid Triggered Catalytic Drug Release, Zhaochun Ma, John-Stephen Taylor*, 2000 Proc. Natl. Acad. Sci. 97, 11159-63.
Cai, J., Li, X., Yue, X., Taylor*, J. S., Nucleic Acid Triggered Fluorescent Probe Activation by the Staudinger Reaction. 2004  J. Am. Chem. Soc., 126,16324-5.

Sun, X., Fang, H., Li, X., Rossin, R., Welch, M. J., Taylor*, J. S.,  MicroPET imaging of MCF-7 tumor in mice via unr mRNA-targeted peptide nucleic acids, 2005 Bioconjug. Chem. 16, 294-305

Vu, B., Cannistraro, V.J., Sun, L. and Taylor, J.S. DNA synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by yeast pol eta is highly nonmutagenic. 2006 Biochemistry, 45, 9327-35.

Su DG, Kao JL, Gross ML, & Taylor JS  Structure determination of an interstrand-type cis-anti cyclobutane thymine dimer produced in high yield by UVB light in an oligodeoxynucleotide at acidic pH 2008 J. Am. Chem. Soc. 130, 11328-11337.

Fang, H., Zhang, K., Shen, G., Wooley, K.L. and Taylor, J.S.  Cationic Shell-crosslinked Knedel-like (cSCK) Nanoparticles for Highly Efficient PNA Delivery. 2009 Molecular Pharmaceutics, in press.

Wang, R. E.; Kao, J. L.-F.; Hilliard, C. A.; Pandita, R. K.; Roti Roti, J. L.; Hunt, C. R.; Taylor, J.-S. Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives  J. Med. Chem. 2009, in press

Courses Taught

List courses: 

Biology 181 Freshman Seminar in Biology
Chemistry 181 Freshman Seminar in Chemistry
Chemistry 251 Organic Chemistry I
Chemistry 252 Organic Chemistry II
Chemistry 257 Organic Chemistry Laboratory
Chemistry 358, Qualitative Organic Analysis Laboratory
Chemistry 453 Bioorganic Chemistry
Chemistry 458 Organic Mechanisms Journal Club
Chemistry 520, Nucleic Acids Chemistry
Biology 5318 DNA Repair
Biology 5432 DNA Structure and Function
Chemistry 558 Spectral Methods in Organic Chemistry
Biology 5911 Special Topics: Mutagenesis adn Repair

Curriculum Vitae: