|
Date |
Class |
Topic |
|
January 13 |
1 |
Introduction, nomenclature, structure, properties of nucleotides |
|
15 |
2 |
Conformational analysis of nucleotides |
|
17 |
3 |
Structure of A, B, Z DNA, triplexes and quadruplexes, tRNA |
|
20 |
4 |
Thermodynamics of DNA duplex formation and RNA folding |
|
22 |
5 |
Chemical and spectroscopic probes of DNA structure and interactions |
|
25 |
6 |
Small molecule interactions: Intercalation and minor groove binding |
|
27 |
7 |
DNA-protein interactions |
|
29 |
8 |
DNA supercoiling |
|
31 |
9 |
DNA bending (Exam I) |
|
February 3 |
10 |
Chemical synthesis of nucleotides, solution phase DNA synthesis |
|
5 |
11 |
Automated DNA and RNA synthesis |
|
7 |
12 |
2D synthesis, synthesis of circular NA, and modified NA (PNA) |
|
10 |
13 |
Enzymatic synthesis of nucleotides, de novo, salvage |
|
|
14 |
Enzymatic synthesis of DNA, RNA, and protein |
|
|
15 |
Physical, chemical, and enzymatic sequencing of DNA and RNA |
|
17 |
16 |
In vitro evolution, SELEX, catalytic DNA |
|
|
17 |
Genetic engineering, site-directed mutagenesis |
|
|
18 |
Protein expression, unnatural mutagenesis, semi-synthetic proteins (Exam II) |
|
24 |
19 |
Photochemistry of DNA |
|
26 |
20 |
Radiation Chemistry |
|
28 |
21 |
Radiomimetic Agents, Footprinting and affinity cleaving |
|
March 10 |
22 |
Covalent Binders/Xenobiotics |
|
12 |
23 |
DNA Repair |
|
14 |
24 |
RNA cleavage chemistry (Exam III) |
|
17 |
25 |
|
|
19 |
26 |
|
|
21 |
27 |
|
|
24 |
28 |
|
|
26 |
29 |
|
|
28 |
30 |
|
|
31 |
31 |
|
|
April 2 |
32 |
|
|
4 |
33 |
|
|
7 |
34 |
|
|
9 |
35 |
|
|
11 |
36 |
|
|
14 |
37 |
|
|
16 |
38 |
|
|
18 |
39 |
|
|
21 |
40 |
|
|
23 |
41 |
|
|
25 |
42 |
|