1. Ian R. Brockie (Spring 1984-Summer 1988) BS, Chemistry, 1983, Rose-Hulman Institute of Technology; Ph.D. 1989, Thesis title: "Design and synthesis of cis-syn and trans-syn Thymine Dimer Building Blocks. Synthesis and Characterization of d(TT[c,s]TT), d(CGTAT[t,s]TATGC) and d(CGTAT[t,s]TATGC)-d(GCATAATACG)." Current position: Sigma Chemical Company, St. Louis.
"A Building Block for the Sequence Specific Introduction of cissyn Thymine Dimers into Oligonucleotides. Solid Phase Synthesis of TpT[c,s]pTpT." JohnStephen Taylor, Ian R. Brockie and Christine L. O'Day, J. Am. Chem. Soc., 1987, 109 67356742.
"Synthesis of a TransSyn Thymine Dimer Building Block. Solid Phase Synthesis of CGTAT[t,s]TATGC." JohnStephen Taylor and Ian R. Brockie, Nucleic Acids Res. 1988, 16, 51235136.
"1H NMR Assignment and Melting Temperature Study of cissyn and transsyn Thymine Dimer Containing-Duplexes of d(CGTATTATGC)·d(GCATAATACG)" JohnStephen Taylor, Daniel Garrett, Ian R. Brockie, Daniel Svoboda and Joshua Telser, Biochemistry 1990, 29, 8858-8866.
Current Position: Sigma, St. Louis.
2. Rushdi Alul, (Spring 1987-Spring 1989) BA, Chemistry, University of Missouri, St. Louis, 1981; Ph.D. 1989. Thesis title: "Design, Synthesis and DNA Binding Properties of a Series of Mono- and Bis(Platinum(II)) Complexes." Postdoctoral with Robert Letsinger at Northwestern in DNA synthesis. Current position: Genetrak, Hopkinton MA
"Synthesis and Characterization of a Series of (dien)Pt(II) Derivatives as Potential Nucleic Acid Conformation and Structure Probes." John-Stephen A. Taylor, Rushdi Alul and Martin B. Cleaver, Inorg. Chem. 199231, 3636-3646.
3. Christine L. O'Day (Spring 1985-Summer 1989) BS, Chemistry, University of Missouri, Columbia, 1984. Thesis Title: "Synthesis and Structure-Activity Relationships of Site-Specific Cis-Syn and Trans-Syn Thymine Dimers." Postdoctoral with John Abelson at Caltech in RNA splicing. Current position: Oridigm, Seattle, WA.
"A Building Block for the Sequence Specific Introduction of cissyn Thymine Dimers into Oligonucleotides. Solid Phase Synthesis of TpT[c,s]pTpT." JohnStephen Taylor, Ian R. Brockie and Christine L. O'Day, J. Am. Chem. Soc., 1987, 109 67356742.
"Synthesis of a Bacteriophage DNA Containing a Site-Specific CisSyn Thymine Dimer" JohnStephen Taylor and Christine L. O'Day, J. Am. Chem. Soc. 1989, 111, 401-402.
"Cis-Syn Thymine Dimers Are Not Absolute Replication Blocks to DNA Polymerase I of E. Coli." John-Stephen Taylor and Christine L. O'Day, Biochemistry, 1990, 29, 1624-1632.
"PCNA-Induced DNA Synthesis Past Cis-Syn and Trans-Syn-I Thymine Dimers by Polymerase in vitro" Christine L. O'Day, Peter M. J. Burgers and John-Stephen Taylor, Nucl. Acids Res. 1992 20, 5403-5406.
4. Michael P. Cohrs (Spring 1985-Summer 1989) BS, Chemistry, Georgia Institute of Technology, 1984. Thesis Title: "Isolation and Characterization of the Dewar Pyrimidinone Photoproduct of TpT. The First Member of a New Class of DNA Photoproducts." Current position: Senior Research Scientist at Armour Pharmaceutical Kankakee, IL.
"DNA, Light and Dewar Pyrimidinones: The Structure and Biological Significance of TpT3." JohnStephen Taylor and Michael P. Cohrs, J. Am. Chem. Soc., 1987, 109, 28342835.
"Solution State Structure of the Dewar Pyrimidinone Photoproduct of Thymidylyl(3'5')thymidine." JohnStephen Taylor, Daniel S. Garrett and Michael P. Cohrs, Biochemistry, 1988, 27, 72067215.
5. Daniel Garrett (Spring 1986-1990) BS, Biochemistry, Manchester College, 1985. Thesis Title: "Combined NMR and Molecular Modeling Studies on Dewar and (6-4) Photoproducts of TpT and d(CGTATTATGC)·d(GCATAATACG) Containing a Cis-Syn Thymine Dimer". Postdoctoral Research Associate with Angela Gronenborn at NIH, Bethesda Maryland. Current: Staff Scientist at NIH, Bethesda Maryland.
"Models for the Solution State Structure of the (64) Photoproduct of Thymidylyl(3'5')thymidine Derived via a Distance and Angle Constrained Conformation Search Procedure." JohnStephen Taylor, Daniel S. Garrett and Michael J. Wang, Biopolymers, 1988, 27, 1571-1593.
"Solution State Structure of the Dewar Pyrimidinone Photoproduct of Thymidylyl(3'5')thymidine." JohnStephen Taylor, Daniel S. Garrett and Michael P. Cohrs, Biochemistry, 1988, 27, 72067215.
"1H NMR Assignment and Melting Temperature Study of cissyn and transsyn Thymine Dimer Containing-Duplexes of d(CGTATTATGC)·d(GCATAATACG)" JohnStephen Taylor, Daniel Garrett, Ian R. Brockie, Daniel Svoboda and Joshua Telser, Biochemistry 1990, 29, 8858-8866.
6. Daniel Svoboda (Fall 1986-1991) BA, Chemistry, 1984, Washington University. Thesis Title: "The role of flanking sequence on the replication and repair of DNA containing single and multiple site specific cis,syn-thymine dimers in vitro". Postdoctoral Research Associate with Aziz Sancar at University of North Carolina, Chapel Hill, Postdoctoral research associate with Jean-Michelle Vos at UNC. Current position: Faculty member at Hopital Maisonneuve-Rosemont, Montreal, Canada. Current position unknown.
"1H NMR Assignment and Melting Temperature Study of cissyn and transsyn Thymine Dimer Containing-Duplexes of d(CGTATTATGC)·d(GCATAATACG)" JohnStephen Taylor, Daniel Garrett, Ian R. Brockie, Daniel Svoboda and Joshua Telser, Biochemistry 1990, 29, 8858-8866.
"Further characterization of eukaryotic nucleotide excision nuclease: Removal of thymine dimer and psoralen monoadduct by HeLa cell free extract and of thymine dimer by xenopus laevis oocytes", Daniel L. Svoboda, John-Stephen Taylor, John E. Hearst, and Aziz Sancar, J. Biol. Chem., 1993, 268, 1931-1936
23. "Effect of Sequence, Adduct Type, and Opposing Lesions on the Binding and Repair of UV Photodamage by DNA Photolyase and (A)BC Excinuclease", Daniel L. Svoboda, Colin A. Smith, John-Stephen A. Taylor, and Aziz Sancar, J. Biol. Chem., 1993, 268, 10694-10700.
7. Michelle Paskiewiecz (Spring 1987-1991) BA, Chemistry, Southern Illinois University, Edwardsville. Thesis Title: "Design and Synthesis of a Potential Bioreductive Alkylator of DNA Based on Anthramycin". Postdoctoral Research Associate, Monsanto Company, St. Louis, Missouri.
Current
position:
Research Scientist Mallinckrodt Company, St. Louis, MO.
8. Jill Zitzewitz (Spring 1987-1991) BA, Chemistry, Carthage College. Thesis title: Multiplicative site-directed mmutagenesis: A new approach to the study of protein folding.
Current
position:
Research associate: Robert Matthews.
9. Nan Jiang (Spring 1988-1991) BS, Chemistry, 1985, Fudan University; MS, Organic Chemistry, 1987, Fudan University, Thesis Title: "In vitro and in vivo replication studies of the cyclobutane photodimers of TpdU and TpT". Postdoctoral research associate, Washington University Medical School, Carl Frieden. Research Scientist at PharMingen, SanDiego CA. Current position: eBiosciences, San Diego, CA. (Company Website).
"In Vivo Evidence that UV-Induced CT Mutations at Dipyrimidine Sites Could Result from the Replicative Bypass of Cis-Syn Cyclobutane Dimers or Their Deamination Products", John-Stephen Taylor and Nan Jiang, Biochemistry,1993, 32, 472-481.
"Mutation Spectra of M13 Vectors Containing Site-Specific Cis-Syn, Trans-Syn-I, Trans-Syn-II, (6-4) and Dewar Pyrimidinone Photoproducts of Thymidylyl-(3'5')-Thymidine in Escherichia coli Under SOS Conditions." Colin A. Smith, Mu Wang, Linda Che, Nan Jiang, and John-Stephen Taylor*, Biochemistry, 1996, 35, 4146-4154.
10. Cheng-I Wang (Spring 1989-1992) BS, Chemistry, 1984, National Tsing Hua. Ph.D. thesis title: "Structure-activity relationships of site-specific cis-syn cyclobutane thymine dimer containing T6 tracts". Postdoctoral Research Associate: University of California, San Francisco, Charles Craik. Then Research Scientist, Neurex, Menlo Park,, CA. Currently a Research Scientist at Zyomyx
"Site-Specific Effect of Thymine Dimer Formation on A-Tract Bending and Its Biological Implications." Cheng-I. Wang and John-Stephen Taylor, Proc. Natl. Acad. Sci. U. S. A. 1991 88, 9072-9077.
"In Vitro Evidence that UV-Induced Frameshift and Substitution Mutations at T-Tracts are the Result of Misalignment-Mediated Replication Past a Specific Thymine Dimer". Cheng-I. Wang and John-Stephen Taylor, Biochemistry1992, 31 3671-3681.
"Photochemically and Photoenzymatically Cleavable DNA" Sourena Nadji, Cheng-I. Wang and John-Stephen Taylor, J. Am. Chem. Soc.. 1992 114, 9266-9269.
"The Trans-Syn-I Thymine Dimer Bends DNA by 22o and Unwinds DNA by 15o", Cheng-I. Wang and John-Stephen Taylor, Chem. Res. Toxicol., 1993, 6, 519-523.
11. Colin Smith (Spring 1989-1993) BS, Chemistry, 1987, Reed College. Ph.D. Thesis title: "In vitro and in vivo mutation spectra of the cis-syn, trans-syn, (6-4) and Dewar photoproducts of TpT at a unique site", Current Position: American Cancer Society Fellow (1994-1997) University of California, San Francisco, Alan Frankel. Then at Larova in Germany. Currently at Mologen, Berlin, Germany (Company Link). (Personal Web Site Link).
"Preparation and Characterization of a Set of Oligonucleotide 49-mers Containing Site-Specific Cis-Syn, Trans-Syn-I, (6-4) and Dewar Photoproducts of TpT Sites." Colin Smith and John-Stephen Taylor, J. Biol. Chem., 1993, 268, 11143-11151.
"Effect of Sequence, Adduct Type, and Opposing Lesions on the Binding and Repair of UV Photodamage by DNA Photolyase and (A)BC Excinuclease", Daniel L. Svoboda, Colin A. Smith, John-Stephen A. Taylor, and Aziz Sancar, J. Biol. Chem., 1993, 268, 10694-10700.
"DNA Photolyase Repairs the Trans-Syn Cyclobutane Thymine Dimer" Sang-Tae Kim, Khushbeer Malhotra, Colin A. Smith, John-Stephen Taylor and Aziz Sancar, Biochemistry, 1993, 32, 7065-7068.
"Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli UvrA Damage recognition protein (uvrA) to the major UV photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T" Joyce T. Reardon, Anne F. Nichols, Scott Keeney, Colin A. Smith, John-Stephen Taylor, Stuart Linn, and Aziz Sancar, J. Biol. Chem. 1993, 268, 21301-21308.
"Characterization of (6-4) photoproduct DNA photolyase", Kim, S.T., Malhotra, K.; Smith, Colin A.; Taylor, John-Stephen; Sancar, Aziz, J. Biol. Chem., 1994, 269, 8535-8540.
"A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6-4 photoproducts." Bowman K K; Sidik K; Smith C A; Taylor J S; Doetsch P W; Freyer, G A, Nucleic Acids Res, 1994 22, 3026-32.
"Mutation Spectra of M13 Vectors Containing Site-Specific Cis-Syn, Trans-Syn-I, Trans-Syn-II, (6-4) and Dewar Pyrimidinone Photoproducts of Thymidylyl-(3'5')-Thymidine in Escherichia coli Under SOS Conditions." Colin A. Smith, Mu Wang, Linda Che, Nan Jiang, and John-Stephen Taylor*, Biochemistry, 1996, 35, 4146-4154.
"The ability of a variety of polymerases to synthesize past site-specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-5')-thymidine." Colin A. Smith, Jared Baeten, and John-Stephen Taylor*. 1998 J. Biol. Chem., 273, 21933-21940.
Professor, American University of Beruit
12. Jeanette Robins Hill (1989-1994) B.S., 1984, Chemistry, Northeast Missouri State. Ph.D. May 1994, Thesis Title: "Study of coiled-coil protein structure-stability relationships using multiplicative site-directed mutagenesis"; Postdoctoral Fellow, Washington University School of Medicine.
13. Lisa Kroutil (1989-1994) BS, Chemistry, University of Missouri, Rolla. Ph.D. May 1994, Thesis title: "Mechanistic studies of misalignment-mediated DNA photoproduct-induced frameshift and substitutuion mutagenesis at T-tracts"; Postdoctoral Fellow, Thomas Kunkel, NIEHS, NC. Visiting Assistant Professor at Beloit College, Beloit, WI.,
Assistant Professor, University of Wisconsin-River Falls. (Unversity Link)
14. Shang Yin (1989-1994). Ph.D. August 1994, Thesis title: "In vitro and in vivo mutation spectra of T-tracts containing site-specific cis-syn and trans-syn cyclobutane thymine dimers" Current Position: Postdoctoral Fellow, Thomas Kunkel, NIEHS, NC.
"Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template", Brian A. Donahue, Shang Yin, John-Stephen Taylor, Daniel Reines, and Phillip C. Hanawalt, Proc. Natl. Acad. Sci.199491, 8502-8506
15. Xiaodong Zhao (1992-1995) Nankai, Ph.D. thesis title "Structure-Activity Relationships of Photoproduct-Specific Antibodies and the TA* Photoproduct" Postdoctoral Fellow, Aziz Sancar, U.N.C. Postdoctoral Fellow, Michael Pirrung, Duke. Amersham-Pharmacia.
"Eliciting a DNA Photoproduct-Specific Antibody with a Dinucleotide Photoproduct Antigen", Xiaodong Zhao and John-Stephen Taylor, J. Am. Chem. Soc., 1994 116 8870-8876.
"Structure of d(TpA)*, the major photoproduct of thymidylyl-(3'-5')-deoxyadenosine. Xiaodong Zhao, Sourena Nadji, Jeffrey Kao, John-Stephen Taylor*, Nucl. Acids Res., 1996, 24, 1554-1560..
"Mutation spectra of TA*, the major photoproduct of thymidylyl(3'-5')-adenosine, in E. coli under SOS induction" Xiaodong Zhao and John-Stephen Taylor*, Nucleic Acids Res. 1996, 24, 1561-1565.
Orchid Biosciences, Princeton NJ (Company Link).
16. Phillip Ordoukhanian (1992-1997) B.S., University of St. Louis; Ph.D. Thesis Title: "Caged DNA", Postdoctoral Fellow, Gerald Joyce, Scripps, La Jolla, CA.
"Design and synthesis of a versatile photocleavable DNA building block. Application to phototriggered hybridization." Ordoukhanian, P; Taylor, J-S., J. Am. Chem. Soc. 1995 117, 9570.
"Solid phase supported thymine dimers for the construction of dimer-containing DNA by combined chemical and enzymatic synthesis. A potentially general method for the efficient incorporation modified nucleotides into DNA." Phillip Ordoukhanian, John-Stephen Taylor*, Nucl. Acids Res. 1997, 3783-3786.
Mu Wang email
17. Mu Wang (Fall 1994-Summer 1998). B.S. Sichuan University, 1986, M.S. Oregon State 1994, Ph.D. thesis title: "In vitro and in vivo mutagenesis studies of cis-syn, trans-syn-I, trans-syn-II, (6-4) and Dewar photoproducts of thymidylyl-(3'-5')-thymidine". Postdoctoral: Suk-Hee Lee, Cancer Research Institute, Indiana University School of Medicine, Indianapolis, Indianna.
"Mutation Spectra of M13 Vectors Containing Site-Specific Cis-Syn, Trans-Syn-I, Trans-Syn-II, (6-4) and Dewar Pyrimidinone Photoproducts of Thymidylyl-(3'® 5')-Thymidine in Escherichia coli Under SOS Conditions." Colin A. Smith, Mu Wang, Linda Che, Nan Jiang, and John-Stephen Taylor*, Biochemistry, 1996, 35, 4146-4154.
Jianquan Liu email
18. Jianquan Liu (Fall 1993-Summer 1998). B.S. Peking University 1987, M.S. Chemistry Institute of Academica Sinica 1990, Ph.D. thesis title: "Photochemistry and photobiology of DNA containing 4-thiothymidine." Postdoctoral: Peter Schultz, Scripps Institute, La Jolla, CA. Postdoctoral with Karen Wolley, Washington University. Quantum Dot, San Francisco (Company Link).
"Remarkable Photoreversal of a Thio Analog of the Dewar Valence Isomer of the (6-4) Photoproduct of DNA to the Parent Nucleotides. Jianquan Liu and John-Stephen Taylor*, J. Am. Chem. Soc. 1996, 118, 3287-3288.
Reaction mechanism of (6-4) photolyase. Xiaodong Zhao, Jianquan Liu, David S. Hsu, Shaying Zhao, John-Stephen Taylor, and Aziz Sancar*. 1997,J. Biol. Chem., 272, 32580-32590.
Template-directed photoligation of
oligonucleotides via 4-thiothymidine. Jianquan Liu and John-Stephen Taylor*, 1998
Nucleic Acids Res.,26, 3300-3304.
Yeuqing Jing email
19. Yeuqing Jing (Fall 1992-Fall 1998). BS Chemistry, Fudan University, 1988, Ph.D. thesis title: "NMR and thermodynamic studies on photoproduct-containing DNA dodecamers", Employment: Research scientist, Monsanto company.
"Thermodynamic and base-pairing studies of matched and mismatched DNA dodecamer duplexes containing cis-syn, (6-4) and Dewar photoproducts of TT." Yeuqing Jing, Jeffrey F.-L. Kao, and John-Stephen Taylor*, 1998Nucl. Acids. Res., 26, 3845-3853.
"Solution-state structure of a DNA dodecamer duplex containing a cis-syn thymine cyclobutane dimer, the major UV photoproduct of DNA." K. McAteer, Y. Jing, J. Kao, J-S. Taylor, M. A. Kennedy*, 1998 J. Mol. Biol., 282, 1013-1032.
Ingrid Ensch-Simon email
20. Ingrid Ensch-Simon (Fall 1993-Summer 1997). Diplom in Biology 1989, University of Bonn, Ph.D. thesis title: "Replication of an SV40 vector containing a cis-syn cyclobutane thymine dimer by human HeLa and Xeroderma pigmentosum variant cell-free extracts" (Ph.D. awarded by the University of Bonn, Germany).
Replicative Bypass of a Site-specific cis-syn thymine dimer in an SV40 vector by HeLa and XPV cell free extracts. Ingrid Ensch-Simon, Peter M. J. Burgers, and John-Stephen Taylor,* 1998 Biochemistry, 37, 8218-8226.
Invitrogen, San Diego, CA (Company Link).
Jody Lingbeck email
21. Jody Lingbeck (Fall 1995-Summer 2000). Postdoc at Washington University Medical School
BS Chemistry 1994 College of St. Benedicts, MN
Structural and thermodynamic studies of photoproduct-containing DNA duplexes.
Preparation and Characterization of DNA Containing a Site-Specific Non-Adjacent Cyclobutane Thymine Dimer of theType Implicated in UV-Induced -1 Frameshift Mutagenesis. Jody Lingbeck, John-Stephen Taylor*, 1999 Biochemistry, 38, 13717-24.
22. Yingie Ren email
B.S.1986, M.S.1988, Bejing Normal, China, M.S. 1995, U. of Alabama.
Synthesis of DNA photoproduct building blocks and photoproduct-containing DNA.
Replication Protein A Interactions with DNA. III. Molecular Basis of Recognition of Damaged DNA. Lao, Y., Gomes, X. V., Ren, Y., Taylor, J.-S., and Wold*, M. S. 2000 Biochemistry 39, 850-859.
Current Position:
23. Yinsheng Wang
Education
B. S. 1993, Shandong University, China
M. S. 1996, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Grad School 1997, SUNY at Albany
Publications
Differentiation of Isomeric Photomodified Oligodeoxynucleotides by fragmentation of Ions Produced by Matrix-assisted Laser Desorption Ionization and Electrospray Ionization. Yinsheng Wang, John-Stephen Taylor, and Michael L. Gross*1999 J. Am. Soc. Mass Spectrom. 10, 329-338.
Nuclease P1 Digestion Combined with Tandem Mass Spectrometry for the Structure Determination of the DNA Photoproducts. Yinsheng Wang, John-Stephen Taylor*, and Michael L. Gross*, 1999 Chem. Res. Toxicol., 12, 1077-1082.
Quantum Chemical Study of the Electron-Transfer-Catalyzed Splitting of Oxetane and Azetidine Intermediates Proposed in the Photoenzymatic Repair of (6-4) Photoproducts of DNA. Yinsheng Wang, Peter P. Gaspar, and John-Stephen Taylor* 2000 J. Am. Chem. Soc., 5510-5519.
A Method for Quantification from Composite Spectra: Application to the Determination of Isomeric DNA Photoproducts by Tandem Mass Spectrometry, Yinsheng Wang, Don L. Rempel, John-Stephen Taylor, and Michael L. Gross* Analytical Chemistry 2001 Anal. Chem. 73, 185-91.
"Fragmentation of
electrospray-produced oligodeoxynucleotide ions adducted to metal ions"
Wang, Y.,
"Isolation and mass
spectrometric characterization of dimeric adenine photoproducts in
oligodeoxynucleotides" Wang, Y.,
Fragmentation of photomodified oligodeoxynucleotides
adducted with metal ions in an electrospray-ionization ion-trap mass
spectrometer. Wang, Y., Taylor, J.S., and Gross, M.L. 2001 J Am Soc Mass Spectrom
12, 1174-1179.
"Use of a Combined Enzymatic Digestion/ESI Mass
Spectrometry Assay to Study the Effect of TATA-Binding Protein on Photoproduct
Formation in a TATA Box" Wang, Y.,
Gross, M. L., and
"Determination of
photomodified oligodeoxynucleotides by exonuclease digestion, matrix-assisted
laser desorption/ionization and post-source decay mass spectrometry"
Zhang, L. K., Ren, Y., Rempel, D.,
Associate Professor of Chemistry at the University of California Riverside
24. Kaijiang Zhang
B.S. 1992 Peking University, China.
Photobiology of DNA photoproducts.
A Caged Ligatable DNA Strand Break. Kaijiang Zhang and John-Stephen Taylor*, 1999 J. Am. Chem. Soc. 121, 11579-11580.
Phototriggered Formation and Repair of DNA Containing a Site-Specific Single Strand Break of the Type Produced by Ionizing Radiation or AP Lyase Activity, Kaijiang Zhang, John-Stephen Taylor*, 2001 Biochemistry 40, 153-159.
Orchid Biosciences, Princeton NJ (Company Link).
25. Wei Li
Education
3D structure determination of photodamaged DNA duplexes by 2D NMR and molecular modeling.
Current Position:
26. Zhaochun Ma (Spring 1996-Spring 2002) Nucleic Acid Triggered Catalytic Drug Release: A New Concept for the Design of Disease-Specific Chemotherapeutic Agents
Nucleic Acid Triggered Catalytic Drug Release. Ma, Z., and Taylor, J.-S. 2000 Proc. Natl. Acad. Sci. USA, 97, 11159-11163.
"Nucleic Acid Triggered Catalytic Drug and Probe
Release: A New Concept for the Design of
Chemotherapeutic and Diagnostic Agents" Ma, Z.,
"PNA-based
RNA-triggered Drug Releasing System"
Ma, Z.,
Research Scientist Applied Biosystems, Forster City, CA.
27. Liping Sun "Study
of dipyrimidine photoproduct translesion synthesis mechanism by DNA replicative
and damage bypass polymerases using structural probes"
Pyrene Nucleotide as a Mechanistic Probe: Evidence for a Transient Abasic-Like Site in
the Bypass of DNA Photoproducts by T7 DNA Polymerase. Liping Sun, Mu Wang, Eric Kool, John-Stephen
Taylor*, 2000 Biochemistry 39, 14603-10.
“Yeast Pol h
Holds a Cis-Syn Thymine Dimer Loosely in the Active Site During Elongation
Opposite the 3'-T of the Dimer, but Tightly Opposite the 5'-T.
Vu, B., Cannistraro, V.J., Sun, L. and Taylor*, J.S. DNA
synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by
yeast pol eta is highly nonmutagenic. Biochemistry,
2006 45, 9327-35.
Postdoctoral Research Associate. Washington University Medical School.
28. Hanshin Hwang " Role of base stacking,
H-bonding, and fingers residue on nucleotide selection opposite the undamaged
and damaged DNA by yeast DNA polymerase eta" Stanford University Postdoc.
Hwang, H., Taylor*, J. S., Role of base stacking and sequence context in the
inhibition of yeast DNA polymerase h by pyrene nucleotide. 2004 Biochemistry, 43, 14612-23.
Hwang, H., Taylor*, J.
S. Evidence for Watson-Crick and
not Hoogsteen or Wobble base pairing in the selection of nucleotides for insertion opposite
pyrimidines and a thymine dimer by yeast DNA pol eta 2005 Biochemistry, 44, 4850-60.
29. Yimin Wang "Design, synthesis and characterization of
N3-alkylated cis-syn thymine dimers"
30. Xuan Xue - "Design and Synthesis of Gene-Specific Agents to Modulate Hyperthermia Induced Radiosensitization", August 30, 2006.
Cai, J., Li, X., Yue, X., Taylor*, J. S., Nucleic Acid Triggered Fluorescent Probe Activation by the Staudinger Reaction. 2004 J. Am. Chem. Soc., 126,16324-5.
Postdoctoral
Research Assistant for David Corey, UT Southwestern.
31. Jianfeng Cai -
Cai,
J., Li, X., Yue, X., Taylor*, J. S., Nucleic Acid Triggered Fluorescent Probe
Activation by the Staudinger Reaction. 2004 J. Am.
Chem. Soc., 126,16324-5.
Cai, J., Li, X., Taylor*,
J. S., Improved Nucleic Acid Triggered Probe Activation Through the Use of a
5-Thiomethyluracil Peptide Nucleic Acid (PNA) Building Block, 2005 Org. Letters, 7, 751-4
Postdoctoral Research Assistant for Andrew Hamilton, Yale Univeristy.
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